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Prenatal cannabis exposure after five to six weeks of pregnancy is associated with attention, social and behavioral problems that persist into early adolescence, according to a  reported yesterday in JAMA Pediatrics. Supported by the National Institute on Drug Abuse, the study is tracking nearly 12,000 youth as they grow into young adults to understand the factors that influence brain, cognitive and social-emotional development. Preclinical studies have shown that delta-9-tetrahydrocannabinol (THC), the main psychoactive substance in cannabis, can cross the placenta and potentially affect brain development. About 5% of pregnant women reported cannabis use in 2019, up from 3% in 2002.