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Eight in 10 U.S. adults say prescription drug costs are “unreasonable,” and one in four say their prescription medicines are difficult to afford, according to the latest Kaiser Family Foundation . The groups most likely to report difficulty affording their medications include people with monthly drug costs of $100 or more, in fair or poor health, with annual incomes under $40,000 or taking at least four drugs monthly. Three in 10 adults reported not taking their medicines as prescribed due to the cost.